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Chart comprehension presents significant challenges for machine learning models due to the diverse and intricate shapes of charts. Existing multimodal methods often over-look these visual features or fail to integrate them effectively for Chart Question Answering. To address this, we introduce CHARTFORMER, a unified framework that enhances chart component recognition by accurately identifying and classifying components such as bars, lines, pies, titles, legends, and axes. Additionally, we propose a novel Question-guided Deformable Co-Attention (QDCAt) mechanism, which fuses chart features encoded by Chart-former with the given question, leveraging the question's guidance to ground the correct answer. Extensive experiments demonstrate a 3.2% improvement in mAP over the baselines for chart component recognition. For ChartQA and OpenCQA tasks, our approach achieves improvements of 15.4% in accuracy and 0.8 in BLEU score, respectively, underscoring the robustness of our solution for detailed visual data interpretation across various applications. 

Estimating biodiversity change across the planet in the context of widespread human modification is a critical challenge. Here, we review how biodiversity has changed in recent decades across scales and taxonomic groups, focusing on four diversity metrics: species richness, temporal turnover, spatial beta-diversity and abundance. At local scales, change across all metrics includes many examples of both increases and declines and tends to be centred around zero, but with higher prevalence of declining trends in beta-diversity (increasing similarity in composition across space or biotic homogenization) and abundance. The exception to this pattern is temporal turnover, with changes in species composition through time observed in most local assemblages. Less is known about change at regional scales, although several studies suggest that increases in richness are more prevalent than declines. Change at the global scale is the hardest to estimate accurately, but most studies suggest extinction rates are probably outpacing speciation rates, although both are elevated. Recognizing this variability is essential to accurately portray how biodiversity change is unfolding, and highlights how much remains unknown about the magnitude and direction of multiple biodiversity metrics at different scales. Reducing these blind spots is essential to allow appropriate management actions to be deployed. This article is part of the theme issue ‘Detecting and attributing the causes of biodiversity change: needs, gaps and solutions’. 

Carbapenem-resistant Enterobacteriaceae continue to threaten human health worldwide with few effective treatment options. New Delhi metallo--lactamase (NDM) enzymes are a contributing element that drive resistance to many -lactam- and carbapenem-based antimicrobials. Many NDM inhibitors are known, yet none are clinically viable. In this study, we present and characterize a new class of NDM-1 inhibitors based on a pyridine-2,6-dithiocarboxylic acid metal complex scaffold. These complexes display varied and unique activity profiles against NDM-1 in kinetic assays and serve to increase the effectiveness of meropenem, an established antibacterial, in assays using clinical Enterobacteriaceae isolates.